Which finding is typically associated with infective endocarditis?

Osler's nodes are painful, raised lesions found on the fingers and toes and are considered a classic manifestation associated with infective endocarditis. They result from the embolization of infectious material or immune complexes that lead to localized inflammation and necrosis. Their presence is indicative of the body's immune response to the infection, thereby serving as a key diagnostic feature in patients suspected of having infective endocarditis.

In contrast, the other findings mentioned do not specifically indicate infective endocarditis. Peripheral edema may occur in various conditions, including heart failure, but is not a hallmark of this infection. Jaundice relates to liver dysfunction or hemolysis and is also not directly associated with endocarditis. Weight gain can result from fluid retention due to different health issues and is not a specific sign of the infection. Therefore, recognizing Osler's nodes as a clinical finding helps healthcare providers in diagnosing and managing infective endocarditis more effectively.