In patients with angina, what effect do calcium channel blockers have?

Calcium channel blockers primarily work by inhibiting the influx of calcium ions into the heart muscle and vascular smooth muscle. This action leads to several beneficial cardiovascular effects. In patients with angina, calcium channel blockers help to reduce myocardial oxygen consumption. By dilating blood vessels, these medications decrease the workload on the heart and lower the heart rate. Consequently, as myocardial oxygen demand decreases and the heart does not have to work as hard, it helps alleviate the symptoms of angina, which often occur due to increased demand for oxygen during physical activity or stress.

The correct choice aligns with the mechanism of action of calcium channel blockers. They effectively decrease the overall oxygen requirements of the myocardium while enhancing coronary blood flow, making them a key treatment option for angina patients.